Clinical outcomes of conjugated linoleic acid supplementation in the overweight and the obese: a study protocol
نویسندگان
چکیده
This is the protocol of a study aiming to assess the impact of conjugated linoleic acid (CLA) on body mass and composition, carbohydrate and fat digestion and absorption, total energy expenditure, lipid profi le, polyunsaturated fatty acids levels, markers of endothelial dysfunction and mineral status in humans. Seventyfour adult volunteers (BMI ≥ 25 kg/m) will be randomized to receive 3.0 g of 80% CLA (50:50 cis-9, trans-11 and trans-10, cis-12 isomers) or 3.0 g of linoleic acid daily for 3 months. A range of parameters will be measured at baseline and after the intervention.
منابع مشابه
Effects of conjugated linoleic acid supplementation on serum levels of interleukin-6 and sirtuin 1 in COPD patients
Objective: Chronic obstructive pulmonary disease (COPD) is characterized by systemic inflammation and accelerated inflammaging of the lungs. Some studies showed that conjugated linoleic acid (CLA) has anti-inflammatory effects. The aim of the present study was to evaluate the effect of CLA supplementationon serum levels of interleukin (IL)-6 and sirtuin1 (SIRT1) in patients wit...
متن کاملEffects of Extruded Flaxseed and Conjugated Linoleic Acid on Growth Performance in Holstein Milk-Fed Calves
The aim of this study was to investigate the effects of extruded flaxseed and conjugated linoleic acid on growth performance, blood parameters in Holstein suckling calves. This experiment was carried out with 30 newborn Holstein calves with an average age of 1-8 days, and about 36±2 kg body weight, with 6 treatments and 5 replications in a completely randomized factorial design (3×2). The treat...
متن کاملConjugated linoleic acid supplementation enhances insulin sensitivity and peroxisome proliferator-activated receptor gamma and glucose transporter type 4 protein expression in the skeletal muscles of rats during endurance exercise
Objective(s):This study examined whether conjugated linoleic acid (CLA) supplementation affects insulin sensitivity and peroxisome proliferator-activated receptor gamma (PPAR-γ) and glucose transporter type 4 (GLUT-4) protein expressions in the skeletal muscles of rats during endurance exercise. Materials and Methods:Sprague-Dawley male rats were randomly divided into HS (high-fat diet (HFD) s...
متن کاملEffect of conjugated linoleic acid on body fat accretion in overweight or obese children.
BACKGROUND Conjugated linoleic acid (CLA) is a supplemental dietary fatty acid that decreases fat mass accretion in young animals. OBJECTIVE The aim of this study was to determine CLA's efficacy with regard to change in fat and body mass index (BMI; in kg/m(2)) in children. DESIGN We conducted a 7 +/- 0.5-mo randomized, double-blind, placebo-controlled trial of CLA in 62 prepubertal childre...
متن کاملThe Effect of Conjugated Linoleic Acid supplementation on the Serum Leptin Level, Pulmonary Function and Quality of Life in COPD Patients
Background & objectives: Chronic Obstructive Pulmonary Disease (COPD) is accompanied by systemic inflammations and is characterized by irreversible airflow limitations. Leptin is a cytokine with pre-inflammatory effect. However, there have been no studies on the effect of conjugated linoleic acid (CLA) on the serum leptin concentration in COPD patients. Therefore, the present study aimed to e...
متن کامل